Violent Hard X-ray Variability of Mrk 421 Observed by NuSTAR in 2013 April

The well studied blazar Markarian 421 (Mrk 421, $z$=0.031) was the subject of an intensive multi-wavelength campaign when it flared in 2013 April. The recorded X-ray and very high energy (VHE, E$>$100 GeV) $\gamma$-ray fluxes are the highest ever measured from this object. At the peak of the activity, it was monitored by the hard X-ray focusing telescope {\it Nuclear Spectroscopic Telescope Array} ({\it NuSTAR}) and {\it Swift} X-Ray Telescope (XRT). In this work, we present a detailed variability analysis of {\it NuSTAR} and {\it Swift}-XRT observations of Mrk 421 during this flaring episode. We obtained the shortest flux doubling time of 14.01$\pm$5.03 minutes, which is the shortest hard X-ray (3$-$79 keV) variability ever recorded from Mrk 421 and is on the order of the light crossing time of the black hole's event horizon. A pattern of extremely fast variability events superposed on slowly varying flares is found in most of the {\it NuSTAR} observations. We suggest that these peculiar variability patterns may be explained by magnetic energy dissipation and reconnection in a fast moving compact emission region within the jet. Based on the fast variability, we derive a lower limit on the magnetic field strength of $B \ge 0.73 \delta_1^{-2/3} \, \nu_{19}^{1/3}$~G, where $\delta_1$ is the Doppler factor in units of 10, and $\nu_{19}$ is the characteristic X-ray synchrotron frequency in units of $10^{19}$~Hz.Comment: 23 pages, 5 figures, 2 tables, to appear in the Astrophysical Journa

A hard gamma-ray flare from 3C 279 in 2013 December

The blazar 3C 279 exhibited twin γ-ray flares of similar intensity in 2013 December and 2014 April. In this work, we present a detailed multi-wavelength analysis of the 2013 December flaring event. Multi-frequency observations reveal the uncorrelated variability patterns with X-ray and optical–UV fluxes peaking after the γ-ray maximum. The broadband spectral energy distribution (SED) at the peak of the γ-ray activity shows a rising γ-ray spectrum but a declining optical–UV flux. This observation along with the detection of uncorrelated variability behavior rules out the one-zone leptonic emission scenario. We, therefore, adopt two independent methodologies to explain the SED: a time-dependent lepto-hadronic modeling and a two-zone leptonic radiative modeling approach. In the lepto-hadronic modeling, a distribution of electrons and protons subjected to a randomly orientated magnetic field produces synchrotron radiation. Electron synchrotron is used to explain the IR to UV emission while proton synchrotron emission is used to explain the high-energy γ-ray emission. A combination of both electron synchrotron self-Compton emission and proton synchrotron emission is used to explain the X-ray spectral break seen during the later stage of the flare. In the two-zone modeling, we assume a large emission region emitting primarily in IR to X-rays and γ-rays to come primarily from a fast-moving compact emission region. We conclude by noting that within a span of four months, 3C 279 has shown the dominance of a variety of radiative processes over each other and this reflects the complexity involved in understanding the physical properties of blazar jets in general

Another look at the BL Lacertae flux and spectral variability

The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical frequencies. During this period, high-energy observations were performed by XMM-Newton, Swift, and Fermi. We analyse these data with particular attention to the calibration of Swift UV data, and apply a helical jet model to interpret the source broad-band variability. The GASP-WEBT observations show an optical flare in 2008 February-March, and oscillations of several tenths of mag on a few-day time scale afterwards. The radio flux is only mildly variable. The UV data from both XMM-Newton and Swift seem to confirm a UV excess that is likely caused by thermal emission from the accretion disc. The X-ray data from XMM-Newton indicate a strongly concave spectrum, as well as moderate flux variability on an hour time scale. The Swift X-ray data reveal fast (interday) flux changes, not correlated with those observed at lower energies. We compare the spectral energy distribution (SED) corresponding to the 2008 low-brightness state, which was characterised by a synchrotron dominance, to the 1997 outburst state, where the inverse-Compton emission was prevailing. A fit with an inhomogeneous helical jet model suggests that two synchrotron components are at work with their self inverse-Compton emission. Most likely, they represent the radiation from two distinct emitting regions in the jet. We show that the difference between the source SEDs in 2008 and 1997 can be explained in terms of pure geometrical variations. The outburst state occurred when the jet-emitting regions were better aligned with the line of sight, producing an increase of the Doppler beaming factor. Our analysis demonstrates that the jet geometry can play an extremely important role in the BL Lacertae flux and spectral variability.Comment: 12 pages, 10 figures, accepted for publication in A&

Development of a new model for rotator cuff pathology: the rabbit subscapularis muscle

Background and purpose The New Zealand white rabbit subscapularis tendon passes under a bony arch to insert on the lesser tubercle of the humerus in a manner analogous to the supraspinatus tendon in humans. We assessed whether this unique anatomy may provide a new animal model of the shoulder to improve our understanding of rotator cuff pathology

The first Fermi multifrequency campaign on BL Lacertae: characterizing the low-activity state of the eponymous blazar

We report on observations of BL Lacertae during the first 18 months of Fermi-LAT science operations and present results from a 48-day multifrequency coordinated campaign from 2008 August 19 to 2008 October 7. The radio to gamma-ray behavior of BL Lac is unveiled during a low activity state thanks to the coordinated observations of radio-band (Metsahovi and VLBA), near-IR/optical (Tuorla, Steward, OAGH and MDM) and X-ray (RXTE and Swift) observatories. No variability was resolved in gamma-rays during the campaign, and the brightness level was 15 times lower than the level of the 1997 EGRET outburst. Moderate and uncorrelated variability has been detected in UV and X-rays. The X-ray spectrum is found to be concave indicating the transition region between the low and high energy component of the spectral energy distribution (SED). VLBA observation detected a synchrotron spectrum self-absorption turnover in the innermost part of the radio jet appearing to be elongated and inhomogeneous, and constrained the average magnetic field there to be less than 3 G. Over the following months BL Lac appeared variable in gamma-rays, showing flares (in 2009 April and 2010 January). There is no evidence for correlation of the gamma-rays with the optical flux monitored from the ground in 18 months. The SED may be described by a single zone or two zone synchrotron self-Compton (SSC) model, but a hybrid SSC plus external radiation Compton (ERC) model seems preferred based on the observed variability and the fact that it provides a fit closest to equipartition.Comment: 14 pages, apj-style emulated, 10 figures. In press by The Astrophysical Journa

A tidal disruption event coincident with a high-energy neutrino

Cosmic neutrinos provide a unique window into the otherwise hidden mechanism of particle acceleration in astrophysical objects. The IceCube Collaboration recently reported the likely association of one high-energy neutrino with a flare from the relativistic jet of an active galaxy pointed towards the Earth. However a combined analysis of many similar active galaxies revealed no excess from the broader population, leaving the vast majority of the cosmic neutrino flux unexplained. Here we present the likely association of a radio-emitting tidal disruption event, AT2019dsg, with a second high-energy neutrino. AT2019dsg was identified as part of our systematic search for optical counterparts to high-energy neutrinos with the Zwicky Transient Facility. The probability of finding any coincident radio-emitting tidal disruption event by chance is 0.5%, while the probability of finding one as bright in bolometric energy flux as AT2019dsg is 0.2%. Our electromagnetic observations can be explained through a multizone model, with radio analysis revealing a central engine, embedded in a UV photosphere, that powers an extended synchrotron-emitting outflow. This provides an ideal site for petaelectronvolt neutrino production. Assuming that the association is genuine, our observations suggest that tidal disruption events with mildly relativistic outflows contribute to the cosmic neutrino flux

Multi-wavelength observations of blazar AO 0235+164 in the 2008-2009 flaring state

The blazar AO 0235+164 (z = 0.94) has been one of the most active objects observed by Fermi Large Area Telescope (LAT) since its launch in Summer 2008. In addition to the continuous coverage by Fermi, contemporaneous observations were carried out from the radio to γ-ray bands between 2008 September and 2009 February. In this paper, we summarize the rich multi-wavelength data collected during the campaign (including F-GAMMA, GASP-WEBT, Kanata, OVRO, RXTE, SMARTS, Swift, and other instruments), examine the cross-correlation between the light curves measured in the different energy bands, and interpret the resulting spectral energy distributions in the context of well-known blazar emission models. We find that the γ-ray activity is well correlated with a series of near-IR/optical flares, accompanied by an increase in the optical polarization degree. On the other hand, the X-ray light curve shows a distinct 20 day high state of unusually soft spectrum, which does not match the extrapolation of the optical/UV synchrotron spectrum. We tentatively interpret this feature as the bulk Compton emission by cold electrons contained in the jet, which requires an accretion disk corona with an effective covering factor of 19% at a distance of 100 R g. We model the broadband spectra with a leptonic model with external radiation dominated by the infrared emission from the dusty torus. © 2012. The American Astronomical Society. All rights reserved

Purification of protein-tyrosine phosphatases from human placenta

This chapter discusses the purification of protein-tyrosine phosphatases from human placenta. Phosphorylation of proteins on tyrosyl residues is an essential element in the control of normal and neoplastic cell growth. The phosphorylation state of a protein reflects the relative activities of the kinase that phosphorylates it and the phosphatase that removes the phosphate. A major technical difficulty associated with the study of protein phosphatases is the requirement for suitably purified phosphorylated substrates. Characterization of the protein-tyrosine phosphatases (PTPases) provides a necessary complementary perspective for an overall understanding of the control of cellular function by tyrosine phosphorylation. This chapter describes procedures for the preparation of substrates and assay of PTPases. It also discusses the purification of a major low-molecular-weight PTPase from human placenta